<!DOCTYPE html>
<html lang="en">
<head>
  <meta charset="UTF-8">
  <meta name="viewport" content="width=device-width, initial-scale=1.0">
  <title>Document</title>
</head>
<body>
  <div id="wrap">
    <button id="btn">提交</button>
  </div>

  <script>
    let wrap = document.getElementById('wrap');
    let btn = document.getElementById('btn');

    // 点那个按钮就记录下来，再去禁用它
    const disabledElements = new WeakSet()
    disabledElements.add(btn)

    btn.addEventListener('click', () => {
      wrap.removeChild(btn)
    })
  </script>
</body>
</html>